a003  2106  18 Jul 82
PM-Advance Advisory,
    
Editors:
    
    The following moved in advance for use today:
    
    PENSACOLA, Fla. - The handbills and a sign at the ramshackle
waterfront bar promise a $50,000 reward to anyone who catches the
proprietor in matching socks. Jon Weissman, also known as Trader Jon,
offered a $500 reward 31 years ago and has increased since. ''I've
never paid off,'' says the unabashed 70-year-old. Slug: PM-Trader
Jonn's, American Style, sent July 16 as a095.
    
    NEW YORK - Business Mirror, a078 of July 16; CORRECTION moved as
a066 of July 17.
    NEW YORK - Radio-TV, a083 of July 16; CORRECTION moved as a052 of
July 17.
    WASHINGTON - Washington Today, a092 of July 16.
    
The AP
 
    
ap-ny-07-19 0005EDT
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a035  0223  17 Jul 82
PM-Tainted Mice,320
Genetically Impure Mice May Affect Cancer Research
By MICHAEL C. BUELOW
Associated Press Writer
    MADISON, Wis. (AP) - Hundreds of previous cancer experiments and
continuing research worldwide could be invalidated because of a
genetic impurity found in a strain of laboratory mice, scientists say.
    ''This is a major contamination problem of almost inestimable
consequence,'' said Robert Auerbach, a zoologist at the University of
Wisconsin. He cited examples of commercial and academic research
projects that were unsuccessful, possibly because of the inconsistent
response of the impure mice.
    Brenda Kahan, another university zoologist, said a nine-month
experiment on mice purchased in January 1981 showed they were not the
genetically pure BALB-c strain, important for cancer research and
other experiments because of their susceptibility to cancer.
    Tests by university researchers and University of Minnesota
immunologists on a second batch ordered in November 1981 confirmed the
impurities, Ms. Kahan said Friday.
    ''It would be as if you bought a chemical that wasn't what was
contained in the bottle,'' said Auerbach, who reported the findings
with Ms. Kahn in Science magazine. ''The damage to research must be
formidable.''
    They said the mice were shipped from Charles River Breeding
Laboratories Inc. in Wilmington, Mass. - the world's largest breeder
of laboratory animals.
    Ms. Kahan said she had no way to estimate how long the company had
unknowingly been shipping the imperfect mice or how many shipments had
been made.
    The company said it became aware of the problem when contacted by
the university in January.
    ''To the best of my knowledge there is no problem now,'' said Wayne
Bolen, a company customer service manager. ''I can't say for sure
there wasn't a problem prior to January. Once we were notified of the
complaint, however, we immediately began testing.''
    
ap-ny-07-17 0523EDT
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